Hyper α2,6‐Sialylation Promotes CD4+ T‐Cell Activation and Induces the Occurrence of Ulcerative Colitis

Abstract α2,6‐sialylation, catalyzed by α2,6‐sialyltransferase (ST6GAL1), plays a pivotal role in immune responses. However, the role of ST6GAL1 in the pathogenesis of ulcerative colitis (UC) remains unknown. ST6GAL1 mRNA is highly expressed in UC tissues compared with the corresponding adjacent nor...

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Bibliographic Details
Main Authors: Qingjie Fan, Mechou Li, Weiwei Zhao, Kaixin Zhang, Ming Li, Wenzhe Li
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
Online Access:https://doi.org/10.1002/advs.202302607