Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson’s disease

Abstract Parkinson’s disease involves multiple neurotransmitter systems beyond the classical dopaminergic circuit, but their influence on structural and functional alterations is not well understood. Here, we use patient-specific causal brain modeling to identify latent neurotransmitter receptor-med...

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Bibliographic Details
Main Authors: Ahmed Faraz Khan, Quadri Adewale, Sue-Jin Lin, Tobias R. Baumeister, Yashar Zeighami, Felix Carbonell, Nicola Palomero-Gallagher, Yasser Iturria-Medina
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41677-w