Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

Non-hematopoietic lymph node stromal cells shape immunity by inducing MHC-I-dependent deletion of self-reactive CD8+ T cells and MHC-II-dependent anergy of CD4+ T cells. In this study, we show that MHC-II expression on lymph node stromal cells is additionally required for homeostatic maintenance of...

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Bibliographic Details
Main Authors: Antonio P Baptista, Ramon Roozendaal, Rogier M Reijmers, Jasper J Koning, Wendy W Unger, Mascha Greuter, Eelco D Keuning, Rosalie Molenaar, Gera Goverse, Marlous M S Sneeboer, Joke M M den Haan, Marianne Boes, Reina E Mebius
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
lymph node stromal cell
regulatory T cell
MHC-II
Online Access:https://elifesciences.org/articles/04433

Internet

https://elifesciences.org/articles/04433

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