Transcriptomic signatures of classical monocytes reveal pro-inflammatory modules and heterogeneity in polyarticular juvenile idiopathic arthritis

Transcriptomic signatures of classical monocytes reveal pro-inflammatory modules and heterogeneity in polyarticular juvenile idiopathic arthritis

IntroductionPolyarticular juvenile idiopathic arthritis (pJIA) is a childhood-onset autoimmune disease. Immune cells contribute to persistent inflammation observed in pJIA. Despite the crucial role of monocytes in arthritis, the precise involvement of classical monocytes in the pathogenesis of pJIA...

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Bibliographic Details
Main Authors: Bidossessi W. Hounkpe, Lucas P. Sales, Surian C. R. Ribeiro, Mariana O. Perez, Valéria F. Caparbo, Diogo Souza Domiciano, Camille P. Figueiredo, Rosa M. R. Pereira, Eduardo F. Borba
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Immunology
Subjects:
polyarticular juvenile idiopathic arthritis
classical monocytes
transcriptomic
inflammation
autoimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1400036/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1400036/full

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