Mutational escape in HIV-1 CTL epitopes leads to increased binding to inhibitory myelomonocytic MHC class I receptors.

Mutational escape in HIV-1 CTL epitopes leads to increased binding to inhibitory myelomonocytic MHC class I receptors.

Escape mutations in HIV-1 cytotoxic T cell (CTL) epitopes can abrogate recognition by the TCR of HIV-1-specific CD8+ T cells, but may also change interactions with alternative MHC class I receptors. Here, we show that mutational escape in three HLA-A11-, B8- and B7- restricted immunodominant HIV-1 C...

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Bibliografiske detaljer
Main Authors: Yue Yang, Jinghe Huang, Ildiko Toth, Mathias Lichterfeld, Xu G Yu
Format: Article
Sprog:English
Udgivet: Public Library of Science (PLoS) 2010-12-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC2999561?pdf=render

Internet

http://europepmc.org/articles/PMC2999561?pdf=render

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