Hijacking PrPC-dependent signal transduction: when prions impair Αβ clearance

Hijacking PrPC-dependent signal transduction: when prions impair Αβ clearance

The cellular prion protein PrPC is the normal counterpart of the scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. The recent discovery that PrPC can serve as a receptor for the amyloid Αβ peptide and relay its neurotoxicity is spar...

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Bibliographic Details
Main Authors: Julia eHernandez-Rapp, Séverine eMartin-Lannerée, Théo Z. Hirsch, Jean-Marie eLaunay, Sophie eMouillet-Richard
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Signal Transduction
Alzheimer's disease
cellular prion protein
prion infection
Αβ clearance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00025/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00025/full

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