Continuous manufacturing of lentiviral vectors using a stable producer cell line in a fixed-bed bioreactor

Continuous manufacturing of lentiviral vectors using a stable producer cell line in a fixed-bed bioreactor

Continuous manufacturing of lentiviral vectors (LVs) using stable producer cell lines could extend production periods, improve batch-to-batch reproducibility, and eliminate costly plasmid DNA and transfection reagents. A continuous process was established by expanding cells constitutively expressing...

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Bibliographic Details
Main Authors: Dale J. Stibbs, Pedro Silva Couto, Yasuhiro Takeuchi, Qasim A. Rafiq, Nigel B. Jackson, Andrea C.M.E. Rayat
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
lentiviral vector
stable producer cell line
continuous bioprocessing
fixed-bed bioreactor
perfusion culture
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124000251

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http://www.sciencedirect.com/science/article/pii/S2329050124000251

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