Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier

Abstract Background A principal protective component of the mammalian blood–brain barrier (BBB) is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2) on the lumenal surface of endothelial cells. The zebrafish P-gp homolog Abc...

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Bibliographic Details
Main Authors: Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Paula B. Salazar, Suresh V. Ambudkar, Michael M. Gottesman
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Fluids and Barriers of the CNS
Subjects:
Zebrafish
ABCG2
Blood–brain barrier
Drug resistance
Online Access:https://doi.org/10.1186/s12987-024-00529-5

Internet

https://doi.org/10.1186/s12987-024-00529-5

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