Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier

Abstract Background A principal protective component of the mammalian blood–brain barrier (BBB) is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2) on the lumenal surface of endothelial cells. The zebrafish P-gp homolog Abc...

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Detalhes bibliográficos
Principais autores: Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Paula B. Salazar, Suresh V. Ambudkar, Michael M. Gottesman
Formato: Artigo
Idioma:English
Publicado em: BMC 2024-03-01
coleção:Fluids and Barriers of the CNS
Assuntos:
Zebrafish
ABCG2
Blood–brain barrier
Drug resistance
Acesso em linha:https://doi.org/10.1186/s12987-024-00529-5

Internet

https://doi.org/10.1186/s12987-024-00529-5

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