A Novel EGFR Targeted Immunotoxin Based on Cetuximab and Type 1 RIP Quinoin Overcomes the Cetuximab Resistance in Colorectal Cancer Cells

A Novel EGFR Targeted Immunotoxin Based on Cetuximab and Type 1 RIP Quinoin Overcomes the Cetuximab Resistance in Colorectal Cancer Cells

Cetuximab is a monoclonal antibody blocking the epidermal growth factor receptor (EGFR) in metastatic colorectal cancer (mCRC). However, cetuximab treatment has no clinical benefits in patients affected by mCRC with KRAS mutation or in the presence of constitutive activation of signalling pathways a...

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Bibliographic Details
Main Authors: Nicola Landi, Vincenza Ciaramella, Sara Ragucci, Angela Chambery, Fortunato Ciardiello, Paolo V. Pedone, Teresa Troiani, Antimo Di Maro
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Toxins
Subjects:
<i>Chenopodium quinoa</i>
chemical conjugation
cytotoxicity
GEO-CR cells
monoclonal antibody
Online Access:https://www.mdpi.com/2072-6651/15/1/57

Internet

https://www.mdpi.com/2072-6651/15/1/57

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