Investigation of the Possible Protective Effect of <i>N</i>-Acetylcysteine (NAC) against Irinotecan (CPT-11)-Induced Toxicity in Rats

Investigation of the Possible Protective Effect of <i>N</i>-Acetylcysteine (NAC) against Irinotecan (CPT-11)-Induced Toxicity in Rats

Irinotecan (CPT-11) is a chemotherapeutic agent involved in the treatment regimens for several malignancies such as colorectal cancer. <i>N</i>-acetylcysteine (NAC) is a strong antioxidant and anti-inflammatory agent used in the treatment of several diseases related to oxidative stress a...

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Bibliographic Details
Main Authors: Sevgi Gençosman, Deniz Ceylanlı, Ahmet Özer Şehirli, Kerem Teralı, Furkan Bölükbaşı, Şule Çetinel, Serkan Sayıner
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Antioxidants
Subjects:
cancer chemotherapy
irinotecan
<i>N</i>-acetylcysteine
matrix metalloproteinase
proinflammatory cytokines
malondialdehyde
Online Access:https://www.mdpi.com/2076-3921/11/11/2219

Internet

https://www.mdpi.com/2076-3921/11/11/2219

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