Homology Modeling, Molecular Docking, Molecular Dynamic Simulation, and Drug-Likeness of the Modified Alpha-Mangostin against the β-Tubulin Protein of <i>Acanthamoeba Keratitis</i>

Homology Modeling, Molecular Docking, Molecular Dynamic Simulation, and Drug-Likeness of the Modified Alpha-Mangostin against the β-Tubulin Protein of <i>Acanthamoeba Keratitis</i>

Acanthamoeba species are capable of causing amoebic keratitis (AK). As a monotherapy, alpha-mangostin is effective for the treatment of AK; however, its bioavailability is quite poor. Moreover, the efficacy of therapy is contingent on the parasite and virulent strains. To improve readiness against A...

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Bibliographic Details
Main Authors: Tassanee Ongtanasup, Anisha Mazumder, Anupma Dwivedi, Komgrit Eawsakul
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
β-tubulin
<i>Acanthamoeba keratitis</i>
additive effect
synergistic effect
pharmacokinetics
Online Access:https://www.mdpi.com/1420-3049/27/19/6338

Internet

https://www.mdpi.com/1420-3049/27/19/6338

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