An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1

An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1

Abstract Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but undefined mechanism. We identify two unusual overlapping Phe-His aromatic pairs within the STIM1 apical helix, one o...

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Bibliographic Details
Main Authors: Yandong Zhou, Michelle R. Jennette, Guolin Ma, Sarah A. Kazzaz, James H. Baraniak, Robert M. Nwokonko, Mallary L. Groff, Marcela Velasquez-Reynel, Yun Huang, Youjun Wang, Donald L. Gill
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42254-x

Internet

https://doi.org/10.1038/s41467-023-42254-x

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