Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2

Summary: The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has caused a huge number of human deaths. Currently, there are no specific drugs or vaccines available for this virus (SARS-CoV-2). The viral polymerase is a promising antiviral target. Here, we describe the near-atomic-reso...

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Bibliographic Details
Main Authors: Qi Peng, Ruchao Peng, Bin Yuan, Jingru Zhao, Min Wang, Xixi Wang, Qian Wang, Yan Sun, Zheng Fan, Jianxun Qi, George F. Gao, Yi Shi
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
SARS-CoV-2
non-structural proteins
polymerase
cofactors
RNA synthesis
cryo-EM
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307543

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http://www.sciencedirect.com/science/article/pii/S2211124720307543

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