Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications
Chemotherapy is widely used to treat patients with cancer. However, resistance to chemotherapeutic drugs remains a major clinical concern. The mechanisms of cancer drug resistance are extremely complex and involve such factors such as genomic instability, DNA repair, and chromothripsis. A recently e...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1092705/full |
| _version_ | 1811175351259234304 |
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| author | Juanjuan Luo Juanjuan Luo Ying Li Tangxuan Zhang Tianhan Xv Chao Chen Mengting Li Qixiang Qiu Yusheng Song Shaogui Wan Shaogui Wan |
| author_facet | Juanjuan Luo Juanjuan Luo Ying Li Tangxuan Zhang Tianhan Xv Chao Chen Mengting Li Qixiang Qiu Yusheng Song Shaogui Wan Shaogui Wan |
| author_sort | Juanjuan Luo |
| collection | DOAJ |
| description | Chemotherapy is widely used to treat patients with cancer. However, resistance to chemotherapeutic drugs remains a major clinical concern. The mechanisms of cancer drug resistance are extremely complex and involve such factors such as genomic instability, DNA repair, and chromothripsis. A recently emerging area of interest is extrachromosomal circular DNA (eccDNA), which forms owing to genomic instability and chromothripsis. eccDNA exists widely in physiologically healthy individuals but also arises during tumorigenesis and/or treatment as a drug resistance mechanism. In this review, we summarize the recent progress in research regarding the role of eccDNA in the development of cancer drug resistance as well as the mechanisms thereof. Furthermore, we discuss the clinical applications of eccDNA and propose some novel strategies for characterizing drug-resistant biomarkers and developing potential targeted cancer therapies. |
| first_indexed | 2024-04-10T19:34:39Z |
| format | Article |
| id | doaj.art-9a10ff2b56744682aa8f9278b0c0598c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T19:34:39Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9a10ff2b56744682aa8f9278b0c0598c2023-01-30T08:22:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10927051092705Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implicationsJuanjuan Luo0Juanjuan Luo1Ying Li2Tangxuan Zhang3Tianhan Xv4Chao Chen5Mengting Li6Qixiang Qiu7Yusheng Song8Shaogui Wan9Shaogui Wan10Center for Molecular Pathology, Department of Basic Medicine, Gannan Medical University, Ganzhou, ChinaChina Medical University, Shenyang, China, Ganzhou, ChinaCenter for Molecular Pathology, Department of Basic Medicine, Gannan Medical University, Ganzhou, ChinaCenter for Molecular Pathology, Department of Basic Medicine, Gannan Medical University, Ganzhou, ChinaCenter for Molecular Pathology, Department of Basic Medicine, Gannan Medical University, Ganzhou, ChinaDepartment of Interventional Radiology, The People’s Hospital of Ganzhou City, Ganzhou, ChinaCenter for Molecular Pathology, Department of Basic Medicine, Gannan Medical University, Ganzhou, ChinaCenter for Molecular Pathology, Department of Basic Medicine, Gannan Medical University, Ganzhou, ChinaDepartment of Interventional Radiology, The People’s Hospital of Ganzhou City, Ganzhou, ChinaCenter for Molecular Pathology, Department of Basic Medicine, Gannan Medical University, Ganzhou, ChinaChina Medical University, Shenyang, China, Ganzhou, ChinaChemotherapy is widely used to treat patients with cancer. However, resistance to chemotherapeutic drugs remains a major clinical concern. The mechanisms of cancer drug resistance are extremely complex and involve such factors such as genomic instability, DNA repair, and chromothripsis. A recently emerging area of interest is extrachromosomal circular DNA (eccDNA), which forms owing to genomic instability and chromothripsis. eccDNA exists widely in physiologically healthy individuals but also arises during tumorigenesis and/or treatment as a drug resistance mechanism. In this review, we summarize the recent progress in research regarding the role of eccDNA in the development of cancer drug resistance as well as the mechanisms thereof. Furthermore, we discuss the clinical applications of eccDNA and propose some novel strategies for characterizing drug-resistant biomarkers and developing potential targeted cancer therapies.https://www.frontiersin.org/articles/10.3389/fonc.2022.1092705/fullcancer geneticsextrachromosomal circular DNAdrug resistancechromothripsisgenomic instability |
| spellingShingle | Juanjuan Luo Juanjuan Luo Ying Li Tangxuan Zhang Tianhan Xv Chao Chen Mengting Li Qixiang Qiu Yusheng Song Shaogui Wan Shaogui Wan Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications Frontiers in Oncology cancer genetics extrachromosomal circular DNA drug resistance chromothripsis genomic instability |
| title | Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications |
| title_full | Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications |
| title_fullStr | Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications |
| title_full_unstemmed | Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications |
| title_short | Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications |
| title_sort | extrachromosomal circular dna in cancer drug resistance and its potential clinical implications |
| topic | cancer genetics extrachromosomal circular DNA drug resistance chromothripsis genomic instability |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1092705/full |
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