Loss of retinoic acid receptor-related receptor alpha (Rorα) promotes the progression of UV-induced cSCC

Abstract Cutaneous squamous cell carcinoma (cSCC) is prevalent in the world, accounting for a huge part of non-melanoma skin cancer. Most cSCCs are associated with a distinct pre-cancerous lesion, the actinic keratosis (AK). However, the progression trajectory from normal skin to AK and cSCC has not...

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Bibliographic Details
Main Authors: Guolong Zhang, Guorong Yan, Zhiliang Fu, Yuhao wu, Fei Wu, Zhe Zheng, Shan Fang, Ying Gao, Xunxia Bao, Yeqiang Liu, Xiuli Wang, Sibo Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03525-x