Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis.

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis.

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Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1. Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficking from late endosomes and lysosomes to the endopl...

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Bibliographic Details
Main Authors: Paula Ortega-Gonzalez, Gwen Taylor, Rohit K Jangra, Raquel Tenorio, Isabel Fernandez de Castro, Bernardo A Mainou, Robert C Orchard, Craig B Wilen, Pamela H Brigleb, Jorna Sojati, Kartik Chandran, Martin Sachse, Cristina Risco, Terence S Dermody
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010322

Internet

https://doi.org/10.1371/journal.ppat.1010322

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