Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group

Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group

Abstract Background Characterization of clinical phenotypes in context with tumor and host genomic information can aid in the development of more effective and less toxic risk-adapted and targeted treatment strategies. To analyze the impact of therapy-related hyperbilirubinemia on treatment outcome...

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Bibliographic Details
Main Authors: Stefanie V. Junk, Elke Schaeffeler, Martin Zimmermann, Anja Möricke, Rita Beier, Peter Schütte, Birthe Fedders, Julia Alten, Laura Hinze, Norman Klein, Andreas Kulozik, Martina U. Muckenthaler, Rolf Koehler, Arndt Borkhardt, Jayaram Vijayakrishnan, David Ellinghaus, Michael Forster, Andre Franke, Astrid Wintering, Christian P. Kratz, Martin Schrappe, Matthias Schwab, Richard S. Houlston, Gunnar Cario, Martin Stanulla
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Childhood acute lymphoblastic leukemia
Treatment-related toxicity
Hepatotoxicity
Hyperbilirubinemia
UGT1A
Online Access:https://doi.org/10.1186/s13046-022-02585-x

Internet

https://doi.org/10.1186/s13046-022-02585-x

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