Integrated transcriptomic and metabolomic profiles reveal the protective mechanism of modified Danggui Buxue decoction on radiation-induced leukopenia in mice

Integrated transcriptomic and metabolomic profiles reveal the protective mechanism of modified Danggui Buxue decoction on radiation-induced leukopenia in mice

Leukopenia caused by radiation hinders the continuous treatment of cancers. Danggui Buxue Decoction (DBD) has been widely used in clinical owing to low toxicity and definite therapeutic effects to increase leukocytes. Meanwhile, icaritin (ICT) has also been proved to have the effect of boosting peri...

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Bibliographic Details
Main Authors: Wei Chen, Jiayun Xin, Xintong Wei, Qianqian Ding, Yunheng Shen, Xike Xu, Yanping Wei, Yanhui Lv, Jie Wang, Zhanhong Li, Weidong Zhang, Xianpeng Zu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
leukopenia
radiation
modified Danggui Buxue decoction (MDBD)
transcriptomics
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1178724/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1178724/full

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