Bruton’s Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae

Bruton’s Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae

Humans with dysfunctional Bruton’s tyrosine kinase (Btk) are highly susceptible to bacterial infections. Compelling evidence indicates that Btk is essential for B cell-mediated immunity, whereas its role in myeloid cell-mediated immunity against infections is controversial. In this study, we determi...

Full description

Bibliographic Details
Main Authors: Zhe Liu, Alexander P.N.A. De Porto, Regina De Beer, Joris J.T.H. Roelofs, Onno J. De Boer, Sandrine Florquin, Cornelis Van’t Veer, Rudi W. Hendriks, Tom Van der Poll, Alex F. De Vos
Format: Article
Language:English
Published: Karger Publishers 2022-05-01
Series:Journal of Innate Immunity
Subjects:
bruton’s tyrosine kinase
klebsiella pneumoniae
innate immunity
neutrophils
reactive oxygen species
Online Access:https://www.karger.com/Article/FullText/524583

Internet

https://www.karger.com/Article/FullText/524583

Similar Items