CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli

CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli

ABSTRACT IncF plasmids are commonly found in extra-intestinal pathogenic Escherichia coli (ExPEC) strains, serving as reservoirs for antimicrobial resistance (AMR) genes and virulence factors, persistently coexisting with ExPEC lineages. Multidrug-resistant (MDR) high-risk ExPEC clones, particularly...

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Bibliographic Details
Main Authors: Liang Chen, Gisele Peirano, Kelly Yen, Bingjie Wang, Austin Terlecky, Rebekah DeVinney, Barry N. Kreiswirth, Johann D. D. Pitout
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:Microbiology Spectrum
Subjects:
extraintestinal pathogenic Escherichia coli
plasmid
CRISPR
pCasCure
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03692-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03692-23

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