Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells

Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells

Abstract Background In the bone marrow, MSCs reside in a hypoxic milieu (1–5% O2) that is thought to preserve their multipotent state. Typically, in vitro expansion of MSCs is performed under normoxia (~ 21% O2), a process that has been shown to impair their function. Here, we evaluated the characte...

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Bibliographic Details
Main Authors: Ben Antebi, Luis A Rodriguez, Kerfoot P Walker, Amber M Asher, Robin M Kamucheka, Lucero Alvarado, Arezoo Mohammadipoor, Leopoldo C Cancio
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells (MSCs)
Hypoxia
Normoxia
Bone marrow
Immunomodulation
Online Access:http://link.springer.com/article/10.1186/s13287-018-1007-x

Internet

http://link.springer.com/article/10.1186/s13287-018-1007-x

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