Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency

Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency

Abstract Background HIV-infected cell lines are widely used to study latent HIV infection, which is considered the main barrier to HIV cure. We hypothesized that these cell lines differ from each other and from cells from HIV-infected individuals in the mechanisms underlying latency. Results To quan...

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Bibliographic Details
Main Authors: Sushama Telwatte, Sara Morón-López, Dvir Aran, Peggy Kim, Christine Hsieh, Sunil Joshi, Mauricio Montano, Warner C. Greene, Atul J. Butte, Joseph K. Wong, Steven A. Yukl
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Retrovirology
Subjects:
HIV-1
Transcription
Latency
Latent infection
Online Access:http://link.springer.com/article/10.1186/s12977-019-0494-x

Internet

http://link.springer.com/article/10.1186/s12977-019-0494-x

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