A high-resolution view of the immune and stromal cell response to Haemophilus ducreyi infection in human volunteers

A high-resolution view of the immune and stromal cell response to Haemophilus ducreyi infection in human volunteers

ABSTRACT Haemophilus ducreyi causes the genital ulcer disease chancroid and cutaneous ulcers in children. To study its pathogenesis, we developed a human challenge model in which we infect the skin on the upper arm of human volunteers with H. ducreyi to the pustular stage of disease. The model has b...

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Bibliographic Details
Main Authors: Julie A. Brothwell, Yuhui Wei, Jia Wang, Tingbo Guo, Chi Zhang, Kate R. Fortney, Rory Duplantier, Li Chen, Teresa A. Batteiger, Mark H. Kaplan, Stanley M. Spinola, Sha Cao
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:mBio
Subjects:
Haemophilus ducreyi
human infection
scRNA-seq
spatial transcriptomics
Online Access:https://journals.asm.org/doi/10.1128/mbio.03885-24

Internet

https://journals.asm.org/doi/10.1128/mbio.03885-24

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