Mesenchymal stem cells combined with liraglutide relieve acute lung injury through apoptotic signaling restrained by PKA/β-catenin

Mesenchymal stem cells combined with liraglutide relieve acute lung injury through apoptotic signaling restrained by PKA/β-catenin

Abstract Background ARDS and ALI are life-threatening diseases with extremely high mortality in patients. Different sources of MSCs could mitigate the symptoms of ALI from diverse mechanisms. Liraglutide is an activator of glucagon-like peptide-1 receptor (GLP-1R) that activates anti-apoptotic pathw...

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Bibliographic Details
Main Authors: Xiaotong Yang, Xiaoying Ma, Ocholi Don, Yuanlin Song, Xiaoyan Chen, Jianwen Liu, Jieming Qu, Yun Feng
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Stem Cell Research & Therapy
Subjects:
ARDS
ALI
Liraglutide
Mesenchymal stem cells
Cell apoptosis
Online Access:http://link.springer.com/article/10.1186/s13287-020-01689-5

Internet

http://link.springer.com/article/10.1186/s13287-020-01689-5

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