Physiological levels of adrenaline fail to stop pancreatic beta cell activity at unphysiologically high glucose levels

Physiological levels of adrenaline fail to stop pancreatic beta cell activity at unphysiologically high glucose levels

Adrenaline inhibits insulin secretion from pancreatic beta cells to allow an organism to cover immediate energy needs by unlocking internal nutrient reserves. The stimulation of α2-adrenergic receptors on the plasma membrane of beta cells reduces their excitability and insulin secretion mostly throu...

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Bibliographic Details
Main Authors: Nastja Sluga, Lidija Križančić Bombek, Jasmina Kerčmar, Srdjan Sarikas, Sandra Postić, Johannes Pfabe, Maša Skelin Klemen, Dean Korošak, Andraž Stožer, Marjan Slak Rupnik
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Endocrinology
Subjects:
adrenaline
islets
beta cells
cAMP
concentration dependency
[Ca2+]c oscillations
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1013697/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.1013697/full

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