Adjuvants and Vaccines Used in Allergen-Specific Immunotherapy Induce Neutrophil Extracellular Traps

Adjuvants and Vaccines Used in Allergen-Specific Immunotherapy Induce Neutrophil Extracellular Traps

Aluminum hydroxide (alum) and monophosphoryl-lipid A (MPLA) are conventional adjuvants in vaccines for allergen-specific immunotherapy (AIT). Alum triggers the release of neutrophil extracellular traps (NETs) by neutrophils. NETs contain expelled decondensed chromatin associated with granular materi...

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Bibliographic Details
Main Authors: Jasmine Karacs, Manuel Reithofer, Claudia Kitzmüller, Markus Kraller, Stefanie Schmalz, Sonja Bleichert, Johannes B. Huppa, Hannes Stockinger, Barbara Bohle, Beatrice Jahn-Schmid
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Vaccines
Subjects:
adjuvants
allergen-specific immunotherapy
aluminum hydroxide
MPLA
neutrophil extracellular traps
monocytes
Online Access:https://www.mdpi.com/2076-393X/9/4/321

Internet

https://www.mdpi.com/2076-393X/9/4/321

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