<i>Isatis tinctoria</i> L. Leaf Extract Inhibits Replicative Senescence in Dermal Fibroblasts by Regulating mTOR-NF-κB-SASP Signaling

<i>Isatis tinctoria</i> L. Leaf Extract Inhibits Replicative Senescence in Dermal Fibroblasts by Regulating mTOR-NF-κB-SASP Signaling

Senescent fibroblasts progressively deteriorate the functional properties of skin tissue. Senescent cells secrete senescence-associated secretory phenotype (SASP) factor, which causes the aging of surrounding non-senescent cells and accelerates aging in the individuals. Recent findings suggested the...

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Bibliographic Details
Main Authors: Jieun Woo, Seoungwoo Shin, Hyanggi Ji, Dehun Ryu, Eunae Cho, Youngseok Kim, Junoh Kim, Deokhoon Park, Eunsun Jung
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Nutrients
Subjects:
<i>Isatis tinctoria</i> L.
senomorphics
replicative senescence
senescence-associated secretory phenotype (SASP)
anti-aging
mTOR pathway
Online Access:https://www.mdpi.com/2072-6643/14/9/1979

Internet

https://www.mdpi.com/2072-6643/14/9/1979

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