Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver DiseaseSummary

Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver DiseaseSummary

Background & Aims: Alcohol-related liver disease (ALD) is characterized by accumulation of hepatic free fatty acids (FFAs) and triglyceride (TG)-enriched lipid droplets and cell death. The present study aimed to investigate how FFA or TG induces hepatocyte injury, thereby contributing to the...

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Bibliographic Details
Main Authors: Wei Guo, Wei Zhong, Liuyi Hao, Haibo Dong, Xinguo Sun, Ruichao Yue, Tianjiao Li, Zhanxiang Zhou
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Free Fatty Acid
DGAT1
Lipotoxicity
Autophagy
Alcohol-Induced Liver Injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21001430

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http://www.sciencedirect.com/science/article/pii/S2352345X21001430

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