Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice
Nociplastic pain, the most recently proposed mechanistic descriptor of chronic pain, is the pain resulting from an altered nociceptive system and network without clear evidence of nociceptor activation, injury or disease in the somatosensory system. As the pain-associated symptoms in many patients s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Neurobiology of Pain |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452073X23000181 |
| _version_ | 1797818655565676544 |
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| author | Manami Yajima Yukari Takahashi Yae K. Sugimura Fusao Kato |
| author_facet | Manami Yajima Yukari Takahashi Yae K. Sugimura Fusao Kato |
| author_sort | Manami Yajima |
| collection | DOAJ |
| description | Nociplastic pain, the most recently proposed mechanistic descriptor of chronic pain, is the pain resulting from an altered nociceptive system and network without clear evidence of nociceptor activation, injury or disease in the somatosensory system. As the pain-associated symptoms in many patients suffering from undiagnosed pain would result from the nociplastic mechanisms, it is an urgent issue to develop pharmaceutical therapies that would mitigate the aberrant nociception in nociplastic pain. We have recently reported that a single injection of formalin to the upper lip shows sustained sensitization lasting for more than 12 days at the bilateral hindpaws, where there is no injury or neuropathy in rats. Using the equivalent model in mice, we show that pregabalin (PGB), a drug used for treating neuropathic pain, significantly attenuates this formalin-induced widespread sensitization at the bilateral hindpaws, even on the 6 day after the initial single orofacial injection of formalin. On the 10th day after formalin injection, the hindlimb sensitization before PGB injection was no more significant in mice receiving daily PGB injections, unlike those receiving daily vehicle injections. This result suggests that PGB would act on the central pain mechanisms that undergo nociplastic changes triggered by initial inflammation and mitigate widespread sensitization resulting from the established changes. |
| first_indexed | 2024-03-13T09:11:09Z |
| format | Article |
| id | doaj.art-9a359a4eb9d34307975e1c188f41249d |
| institution | Directory Open Access Journal |
| issn | 2452-073X |
| language | English |
| last_indexed | 2024-03-13T09:11:09Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Pain |
| spelling | doaj.art-9a359a4eb9d34307975e1c188f41249d2023-05-27T04:26:22ZengElsevierNeurobiology of Pain2452-073X2023-01-0113100131Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in miceManami Yajima0Yukari Takahashi1Yae K. Sugimura2Fusao Kato3Center for Neuroscience of Pain and Department of Neuroscience, The Jikei University School of Medicine, Tokyo, Japan; Department of Dental Anesthesiology, School of Dental Medicine, Tsurumi University, Yokohama, JapanCenter for Neuroscience of Pain and Department of Neuroscience, The Jikei University School of Medicine, Tokyo, JapanCenter for Neuroscience of Pain and Department of Neuroscience, The Jikei University School of Medicine, Tokyo, JapanCenter for Neuroscience of Pain and Department of Neuroscience, The Jikei University School of Medicine, Tokyo, Japan; Corresponding author at: Center for Neuroscience of Pain, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, Japan.Nociplastic pain, the most recently proposed mechanistic descriptor of chronic pain, is the pain resulting from an altered nociceptive system and network without clear evidence of nociceptor activation, injury or disease in the somatosensory system. As the pain-associated symptoms in many patients suffering from undiagnosed pain would result from the nociplastic mechanisms, it is an urgent issue to develop pharmaceutical therapies that would mitigate the aberrant nociception in nociplastic pain. We have recently reported that a single injection of formalin to the upper lip shows sustained sensitization lasting for more than 12 days at the bilateral hindpaws, where there is no injury or neuropathy in rats. Using the equivalent model in mice, we show that pregabalin (PGB), a drug used for treating neuropathic pain, significantly attenuates this formalin-induced widespread sensitization at the bilateral hindpaws, even on the 6 day after the initial single orofacial injection of formalin. On the 10th day after formalin injection, the hindlimb sensitization before PGB injection was no more significant in mice receiving daily PGB injections, unlike those receiving daily vehicle injections. This result suggests that PGB would act on the central pain mechanisms that undergo nociplastic changes triggered by initial inflammation and mitigate widespread sensitization resulting from the established changes.http://www.sciencedirect.com/science/article/pii/S2452073X23000181GabapentinoidsInflammation-induced widespread painvon Frey filament testCentral sensitizationEctopic sensitizationOrofacial inflammatory pain |
| spellingShingle | Manami Yajima Yukari Takahashi Yae K. Sugimura Fusao Kato Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice Neurobiology of Pain Gabapentinoids Inflammation-induced widespread pain von Frey filament test Central sensitization Ectopic sensitization Orofacial inflammatory pain |
| title | Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice |
| title_full | Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice |
| title_fullStr | Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice |
| title_full_unstemmed | Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice |
| title_short | Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice |
| title_sort | pregabalin attenuates long lasting post inflammatory nociplastic mechanical sensitization in mice |
| topic | Gabapentinoids Inflammation-induced widespread pain von Frey filament test Central sensitization Ectopic sensitization Orofacial inflammatory pain |
| url | http://www.sciencedirect.com/science/article/pii/S2452073X23000181 |
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