CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response

CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response

Abstract Background The Alzheimer’s disease (AD) risk gene ABCA7 has suggested functions in lipid metabolism and the immune system. Rare premature termination codon (PTC) mutations and an expansion of a variable number of tandem repeats (VNTR) polymorphism in the gene, both likely cause a lower ABCA...

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Bibliographic Details
Main Authors: Lena Duchateau, Fahri Küҫükali, Arne De Roeck, Mandy M. J. Wittens, Joke Temmerman, Ilse Weets, Maarten Timmers, Sebastiaan Engelborghs, Maria Bjerke, Kristel Sleegers
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
ABCA7
PTC mutation
VNTR expansion
CSF biomarkers
Alzheimer’s disease
Inflammation
Online Access:https://doi.org/10.1186/s13195-023-01338-y

Internet

https://doi.org/10.1186/s13195-023-01338-y

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