Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.

Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.

Alongshan virus (ALSV), a newly discovered member of unclassified Flaviviridae family, is able to infect humans. ALSV has a multi-segmented genome organization and is evolutionarily distant from canonical mono-segmented flaviviruses. The virus-encoded methyltransferase (MTase) plays an important rol...

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Bibliographic Details
Main Authors: Hua Chen, Sheng Lin, Fanli Yang, Zimin Chen, Liyan Guo, Jing Yang, Xi Lin, Lingling Wang, Yanping Duan, Ao Wen, Xindan Zhang, Yushan Dai, Keqing Yin, Xin Yuan, Chongzhang Yu, Yarong He, Bin He, Yu Cao, Haohao Dong, Jian Li, Qi Zhao, Quan Liu, Guangwen Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-10-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011694&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011694&type=printable

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