Use of quantitative mass spectrometry-based proteomics and ELISA to compare the alpha 2 macroglobulin concentration in equine blood-based products processed by three different orthobiologic devices

Use of quantitative mass spectrometry-based proteomics and ELISA to compare the alpha 2 macroglobulin concentration in equine blood-based products processed by three different orthobiologic devices

IntroductionAlpha 2 macroglobulin (A2M), a multi-functional protein in the plasma protease inhibitor class, regulates proinflammatory cytokines and the clearance of chondrodestructive enzymes in cases of joint injury and osteoarthritis (OA). The purpose of this study was to compare A2M concentration...

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Bibliographic Details
Main Authors: Kyla F. Ortved, Larry Alward, Bobby Cowles, Renata Linardi, Dhvani Barot, Alex Usimaki, Joseph R. Fedie, Deb Amodie, Laurie R. Goodrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Veterinary Science
Subjects:
alpha 2 macroglobulin
equine
protease inhibitor
proteomic
regenerative joint disease therapy
selected reaction monitoring
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2024.1335972/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2024.1335972/full

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