NMDA antagonists recreate signal-to-noise ratio and timing perturbations present in schizophrenia

Rationale: There is increasing evidence that functional deficits in schizophrenia may be driven by a reduction in the signal-to-noise ratio (SNR) and consistent timing of neural signals. This study examined the extent to which exposure to the NMDA receptor antagonists ketamine and MK801, frequently...

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Bibliographic Details
Main Authors: John A. Saunders, Michael J. Gandal, Steve J. Siegel
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000046