Enhanced Nasal Deposition and Anti-Coronavirus Effect of Favipiravir-Loaded Mucoadhesive Chitosan–Alginate Nanoparticles

Enhanced Nasal Deposition and Anti-Coronavirus Effect of Favipiravir-Loaded Mucoadhesive Chitosan–Alginate Nanoparticles

Favipiravir (FVR) is a repurposed antiviral drug for treating mild to moderate cases of the novel coronavirus disease 2019 (COVID-19). However, its poor solubility and permeability limit its clinical efficacy. To overcome its physicochemical and pharmacokinetic limitations, we statistically designed...

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Bibliographic Details
Main Authors: Khent Primo Alcantara, Nonthaneth Nalinratana, Nopporn Chutiwitoonchai, Agnes L. Castillo, Wijit Banlunara, Opa Vajragupta, Pornchai Rojsitthisak, Pranee Rojsitthisak
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
response surface methodology
Box–Behnken design
chitosan
alginate
SARS-CoV-2
antiviral
Online Access:https://www.mdpi.com/1999-4923/14/12/2680

Internet

https://www.mdpi.com/1999-4923/14/12/2680

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