An autosomal recessive mutation in SCL24A4 causing enamel hypoplasia in Samoyed and its relationship to breed-wide genetic diversity

An autosomal recessive mutation in SCL24A4 causing enamel hypoplasia in Samoyed and its relationship to breed-wide genetic diversity

Abstract Background Pure breeding of dogs has led to over 700 heritable disorders, of which almost 300 are Mendelian in nature. Seventy percent of the characterized mutations have an autosomal recessive mode of inheritance, indicative of positive selection during bouts of inbreeding primarily for ne...

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Bibliographic Details
Main Authors: Niels C. Pedersen, Bonnie Shope, Hongwei Liu
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Canine Genetics and Epidemiology
Subjects:
Canis familiaris
Samoyed
Familial enamel hypoplasia
SLC24A4
Short tandem repeats (STRs)
Genetic diversity
Online Access:http://link.springer.com/article/10.1186/s40575-017-0049-1

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http://link.springer.com/article/10.1186/s40575-017-0049-1

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