Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target

Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target

Summary: KRAS inhibitor AMG510 covalently modifies the G12C residue and inactivates the KRAS/G12C function. Because there are many reactive cysteines in the proteome, it is important to characterize AMG510 on-target modification and off-targets. Here, we presented a streamlined workflow to measure a...

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Bibliographic Details
Main Authors: Yini Wang, Bowen Zhong, Caixia Xu, Dongdong Zhan, Songhao Zhao, Hongxing Wu, Mingwei Liu, Xiaoling Lan, Danni Cai, Qian Ding, Biao Zheng, Jiong Lan, Qiang Lv, Yi Wang, Jun Qin
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Biochemistry methods
Proteomics
Biochemical assay
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223001578

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http://www.sciencedirect.com/science/article/pii/S2589004223001578

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