Identification of Germline <i>FOXE1</i> and Somatic <i>MAPK</i> Pathway Gene Alterations in Patients with Malignant Struma Ovarii, Cleft Palate and Thyroid Cancer

Identification of Germline <i>FOXE1</i> and Somatic <i>MAPK</i> Pathway Gene Alterations in Patients with Malignant Struma Ovarii, Cleft Palate and Thyroid Cancer

Germline variants in the FOXE1 transcription factor have been associated with thyroid ectopy, cleft palate (CP) and thyroid cancer (TC). Here, we aimed to clarify the role of <i>FOXE1</i> in Portuguese families (F1 and F2) with members diagnosed with malignant struma ovarii (MSO), an ova...

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Bibliographic Details
Main Authors: Carolina Pires, Ana Saramago, Margarida M. Moura, Jing Li, Sara Donato, Inês J. Marques, Hélio Belo, Ana C. Machado, Rafael Cabrera, Thomas G. P. Grünewald, Valeriano Leite, Branca M. Cavaco
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
thyroid cancer
malignant struma ovarii
cleft palate
thyroid ectopy
genomics
molecular tumour pathology
Online Access:https://www.mdpi.com/1422-0067/25/4/1966

Internet

https://www.mdpi.com/1422-0067/25/4/1966

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