Astrocytic 5-HT1A receptor mediates age-dependent hippocampal LTD and fear memory extinction in male mice

Abstract NMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. Although the underlying mechanisms remain unclear, this form of LTD cannot be induced by low-frequency stimulation (LFS) i...

Full description

Bibliographic Details
Main Authors: Qian-Yun Wu, Lian-Hong Lin, Kun Lu, Si-Fu Deng, Wei-Min Li, Yuan Xu, Bin Zhang, Ji-Hong Liu
Format: Article
Language:English
Published: Nature Publishing Group 2024-08-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01285-0