MALAT1 as a Regulator of the Androgen-Dependent Choline Kinase A Gene in the Metabolic Rewiring of Prostate Cancer

MALAT1 as a Regulator of the Androgen-Dependent Choline Kinase A Gene in the Metabolic Rewiring of Prostate Cancer

Background. Choline kinase alpha (CHKA), an essential gene in phospholipid metabolism, is among the modulated MALAT1-targeted transcripts in advanced and metastatic prostate cancer (PCa). Methods. We analyzed CHKA mRNA by qPCR upon MALAT1 targeting in PCa cells, which is characterized by high dose-r...

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Bibliographic Details
Main Authors: Sara De Martino, Egidio Iorio, Chiara Cencioni, Aurora Aiello, Francesco Spallotta, Mattea Chirico, Maria Elena Pisanu, Claudio Grassi, Alfredo Pontecorvi, Carlo Gaetano, Simona Nanni, Antonella Farsetti
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
choline kinase A
prostate cancer
MALAT1
metabolic rewiring
phospholipid metabolism
Online Access:https://www.mdpi.com/2072-6694/14/12/2902

Internet

https://www.mdpi.com/2072-6694/14/12/2902

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