Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s disease

Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s disease

Huntington’s disease (HD) is a progressive dominantly inherited neurodegenerative disease caused by the expansion of a cytosine-adenine-guanine (CAG) trinucleotide repeat in the huntingtin gene, which encodes the mutant huntingtin protein containing an expanded polyglutamine tract. One of neuropatho...

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Bibliographic Details
Main Authors: Chen Xu, Sidong Chen, Xingxiang Chen, Ka Hei Ho, Chungwon Park, Hanna Yoo, Suk-Ho Lee, Hyokeun Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Huntington’s disease
synaptic vesicle
exocytosis
inhibitory synapses
real-time imaging
presynaptic terminal
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1175522/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1175522/full

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