Reversible lysine acetylation regulates nuclear translocation of TyrRS to counteract genotoxic oxidative stress

Aminoacyl-tRNA synthetases, catalyzing the first step of protein synthesis, have been shown to involve with multiple additional physiologic responses. Here, we summarize our findings that p300/CBP-Associated Factor and Sirtuin 1 play the reversible acetylation role in regulating the nuclear transloc...

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Bibliographic Details
Main Authors: Chaoqun Li, Wei Yu
Format: Article
Language:English
Published: Taylor & Francis Group 2017-05-01
Series:Molecular & Cellular Oncology
Subjects:
Online Access:http://dx.doi.org/10.1080/23723556.2017.1293597