Cell-Type-Dependent Role for nsP3 Macrodomain ADP-Ribose Binding and Hydrolase Activity during Chikungunya Virus Infection

Cell-Type-Dependent Role for nsP3 Macrodomain ADP-Ribose Binding and Hydrolase Activity during Chikungunya Virus Infection

Chikungunya virus (CHIKV) causes outbreaks of rash, arthritis, and fever associated with neurologic complications, where astrocytes are preferentially infected. A determinant of virulence is the macrodomain (MD) of nonstructural protein 3 (nsP3), which binds and removes ADP-ribose (ADPr) from ADP-ri...

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Bibliographic Details
Main Authors: Taewoo Kim, Rachy Abraham, Lisa Pieterse, Jane X. Yeh, Diane E. Griffin
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Viruses
Subjects:
chikungunya virus
macrodomain
alphavirus
ADP ribosylation
replication complexes
viral replication
Online Access:https://www.mdpi.com/1999-4915/14/12/2744

Internet

https://www.mdpi.com/1999-4915/14/12/2744

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