A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport

A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport

Abstract Background Receptor-mediated transcytosis is one of the major routes for drug delivery of large molecules into the brain. The aim of this study was to develop a novel model of the human blood–brain barrier (BBB) in a high-throughput microfluidic device. This model can be used to assess pass...

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Bibliographic Details
Main Authors: Nienke R. Wevers, Dhanesh G. Kasi, Taylor Gray, Karlijn J. Wilschut, Benjamin Smith, Remko van Vught, Fumitaka Shimizu, Yasuteru Sano, Takashi Kanda, Graham Marsh, Sebastiaan J. Trietsch, Paul Vulto, Henriëtte L. Lanz, Birgit Obermeier
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Microfluidics
Organ-on-a-chip
BBB
Antibody transcytosis
Online Access:http://link.springer.com/article/10.1186/s12987-018-0108-3

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http://link.springer.com/article/10.1186/s12987-018-0108-3

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