Guanxinning injection ameliorates cardiac remodeling in HF mouse and 3D heart spheroid models via p38/FOS/MMP1-mediated inhibition of myocardial hypertrophy and fibrosis

Guanxinning injection ameliorates cardiac remodeling in HF mouse and 3D heart spheroid models via p38/FOS/MMP1-mediated inhibition of myocardial hypertrophy and fibrosis

Background: Heart failure (HF) is a cardiovascular disease with high morbidity and mortality. Guanxinning injection (GXNI) is clinically used for the treatment of coronary heart disease, but its therapeutic efficacy and potential mechanism for HF are poorly understood. This study aimed to evaluate t...

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Bibliographic Details
Main Authors: Siwen Fan, Guangxu Xiao, Jingyu Ni, Yuhan Zhao, Hongying Du, Yingran Liang, Ming Lv, Shuang He, Guanwei Fan, Yan Zhu
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Guanxinning injection
Heart failure
Cardiac spheroids
Cardiac remodeling
FOS
IL-17A signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223004304

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http://www.sciencedirect.com/science/article/pii/S0753332223004304

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