Synthesis and initial in vitro evaluation of olmutinib derivatives as prospective imaging probe for non-small cell lung cancer

Synthesis and initial in vitro evaluation of olmutinib derivatives as prospective imaging probe for non-small cell lung cancer

Introduction: Imaging a non-small cell lung cancer (NSCLC) using radiolabeled tyrosine kinase inhibitors (TKIs) has attracted attention due to their unique interaction with the target epidermal growth factor receptor (EGFR). Olmutinib (OTB) is one of the third-generation EGFR TKIs, which selectively...

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Bibliographic Details
Main Authors: Muammar Fawwaz, Kenji Mishiro, Arwansyah Arwansyah, Ryuichi Nishii, Kazuma Ogawa
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2024-01-01
Series:BioImpacts
Subjects:
cytotoxicity
l858r/t790m
molecular docking
tyrosine kinase inhibitor
Online Access:https://bi.tbzmed.ac.ir/PDF/bi-14-27774.pdf

Internet

https://bi.tbzmed.ac.ir/PDF/bi-14-27774.pdf

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