Photocaging of Pyridinylimidazole-Based Covalent JNK3 Inhibitors Affords Spatiotemporal Control of the Binding Affinity in Live Cells

Photocaging of Pyridinylimidazole-Based Covalent JNK3 Inhibitors Affords Spatiotemporal Control of the Binding Affinity in Live Cells

The concept of photocaging represents a promising approach to acquire spatiotemporal control over molecular bioactivity. To apply this strategy to pyridinylimidazole-based covalent JNK3 inhibitors, we used acrylamido-<i>N</i>-(4-((4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1<i>H...

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Bibliographic Details
Main Authors: Beate Sandra Hoffelner, Stanislav Andreev, Nicole Plank, Pierre Koch
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
kinase inhibitor
pyridinyl imidazole
covalent inhibitor
photoactivation
caging group
JNK3
Online Access:https://www.mdpi.com/1424-8247/16/2/264

Internet

https://www.mdpi.com/1424-8247/16/2/264

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