Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Preeclampsia (PE) is a rising, potentially lethal complication of pregnancy. PE is driven primarily by the overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1), a validated diagnostic and prognostic marker of the disease when normalized to placental growth factor (PlGF) levels. Inj...

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Bibliographic Details
Main Authors: Sarah M. Davis, Vignesh N. Hariharan, Agnes Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi, Melissa J. Moore, Anastasia Khvorova
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
siRNA therapeutics
oligonucleotides
preeclampsia
oligonucleotide drug design
extrahepatic delivery
angiogenic disorders
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122001615

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http://www.sciencedirect.com/science/article/pii/S2162253122001615

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