E protein binding at the Tcra enhancer promotes Tcra repertoire diversity
V(D)J recombination of antigen receptor loci is a highly developmentally regulated process. During T lymphocyte development, recombination of the Tcra gene occurs in CD4+CD8+ double positive (DP) thymocytes and requires the Tcra enhancer (Eα). E proteins are known regulators of DP thymocyte developm...
Główni autorzy: | , , , |
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Format: | Artykuł |
Język: | English |
Wydane: |
Frontiers Media S.A.
2023-07-01
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Seria: | Frontiers in Immunology |
Hasła przedmiotowe: | |
Dostęp online: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188738/full |