E protein binding at the Tcra enhancer promotes Tcra repertoire diversity

E protein binding at the Tcra enhancer promotes Tcra repertoire diversity

V(D)J recombination of antigen receptor loci is a highly developmentally regulated process. During T lymphocyte development, recombination of the Tcra gene occurs in CD4+CD8+ double positive (DP) thymocytes and requires the Tcra enhancer (Eα). E proteins are known regulators of DP thymocyte developm...

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Bibliographic Details
Main Authors:	Ariana Mihai, Sumedha Roy, Michael S. Krangel, Yuan Zhuang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Series:	Frontiers in Immunology
Subjects:	E proteins Tcra enhancer V(D)J recombination T cells Thymus
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188738/full

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