Adaption of an Episomal Antisense Silencing Approach for Investigation of the Phenotype Switch of Staphylococcus aureus Small-Colony Variants

Adaption of an Episomal Antisense Silencing Approach for Investigation of the Phenotype Switch of Staphylococcus aureus Small-Colony Variants

Staphylococcus aureus small-colony variants (SCVs) are associated with chronic, persistent, and relapsing courses of infection and are characterized by slow growth combined with other phenotypic and molecular traits. Although certain mechanisms have been described, the genetic basis of clinical SCVs...

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Bibliographic Details
Main Authors: Nina Schleimer, Ursula Kaspar, Britta Ballhausen, Sarah A. Fotiadis, Jessica M. Streu, André Kriegeskorte, Richard A. Proctor, Karsten Becker
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Microbiology
Subjects:
Staphylococcus aureus
small-colony variant (SCV)
antisense silencing
phenotype switch
enoyl-acyl-carrier-protein reductase gene (fabI)
tet-regulatory expression system
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02044/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.02044/full

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